It has been ten years since the Raccoon City incident and the President of the United States has decided to reveal the truth behind what took place in the belief that it will curb the current resurgence in bio-terrorist activity. Due to be by the President is side is his personal friend and Raccoon City survivor, Leon S. Kennedy, but when the venue suffers a bio-terrorist attack, Leon is forced to face a President transformed beyond recognition and make his hardest ever decision.